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In contrast, the ZDHHC9-mediated palmitoylation of -catenin promotes its ubiquitination and degradation, thereby protecting against renal fibrosis [66]

The clinical application of alpha-lipoic acid in metabolic dysfunction-associated steatotic liver disease Metabolic Dysfunction-associated Steatotic Liver Disease is a chronic liver disease characterized by excessive fat accumulation in the liver, insulin resistance, oxidative stress and inflammatory responses, which can progress to non-alcoholic steatohepatitis, fibrosis, cirrhosis and even hepatocellular carcinoma